Genetic Determinants of White Matter Hyperintensities on Brain Scans
نویسندگان
چکیده
منابع مشابه
Genetic Determinants of White Matter Hyperintensities on Brain Scans
Background and Purpose—White matter hyperintensities (WMH) are highly heritable and associated with small artery ischemic stroke, so they may be a useful trait for studying the genetics of small vessel disease. Many studies have attempted to find associations between polymorphisms in various candidate genes and WMH. We aimed to evaluate the evidence for these associations by performing a system...
متن کاملGenetic determinants of white matter hyperintensities on brain scans: a systematic assessment of 19 candidate gene polymorphisms in 46 studies in 19,000 subjects.
BACKGROUND AND PURPOSE White matter hyperintensities (WMH) are highly heritable and associated with small artery ischemic stroke, so they may be a useful trait for studying the genetics of small vessel disease. Many studies have attempted to find associations between polymorphisms in various candidate genes and WMH. We aimed to evaluate the evidence for these associations by performing a system...
متن کاملWhite matter hyperintensities on brain magnetic resonance in systemic sclerosis.
OBJECTIVE To evaluate the brain status of patients with systemic sclerosis (SSc). METHODS Fourteen female patients with SSc aged 24-74, with a disease duration of 1-12 years and without other relevant systemic diseases, were enrolled. All patients and an age matched female control group (CG) of 14 clinically normal subjects, underwent brain magnetic resonance examination at 1.5 T; spin echo p...
متن کاملNormalized brain volume and white matter hyperintensities as determinants of cerebral blood flow in Alzheimer’s disease
Purpose: Patients with Alzheimer’s disease (AD) have a lower cerebral blood flow (CBF) compared to the general elderly population. It is still not fully understood whether this decreased CBF reflects neurodegeneration, or rather is the consequence of comorbid cerebral small vessel disease (SVD). We aimed to investigate the independent associations of normalized brain volume (NBV) and white matt...
متن کاملBrain volume and white matter hyperintensities as determinants of cerebral blood flow in Alzheimer's disease.
To better understand whether decreased cerebral blood flow (CBF) in patients with Alzheimer's disease (AD) reflects neurodegeneration or cerebral small vessel disease, we investigated the associations of normalized brain volume (NBV) and white matter hyperintensity (WMH) volume with CBF. We included 129 patients with AD (66 ± 7 years, 53% female) and 61 age-matched controls (64 ± 5 years, 43% f...
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ژورنال
عنوان ژورنال: Stroke
سال: 2009
ISSN: 0039-2499,1524-4628
DOI: 10.1161/strokeaha.108.542050